About us
We are interested in understanding organ-specific Endothelial Cell function, and in dissecting the interactions between EC and other cells in health and disease.
ENDOTHELIAL CELL FUNCTION is rooted in METABOLISM, and affects important parameters, including cytokine secretion, inflammation, ECM remodelling and organ microenvironment, fundamentally modulating ORGAN HOMEOSTASIS
We use both in vivo and ex vivo models to identify the role of the vasculature in organ function and remodelling, specifically in the context of secondary (metastatic) Breast Cancer.
Unlike their epithelial relatives, the endothelium is a plastic and versatile organ, that dynamically adapts to the demands of the organ it supplies. It is ideally placed to coordinate information and protect organ function. It is also an ideal target to treat a myriad of conditions that appear as a result of or are exacerbated by microvascular dysfunction.
Meet the group members and individual projects, and navigate our site for more details and updates on what happens in and around the lab.
Check our Institutional webpage here
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Banner image: VE-cadherin staining (green) of murine primary microvascular endothelial cells from (left to right) liver, brain and kidney. Nuclei stained with DAPI. Credit to Aileen Burke
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